The (re)challenging question of erythropoiesis-stimulating agents inducing pure red cell aplasia
نویسندگان
چکیده
منابع مشابه
[Diagnosis and treatment of pure red-cell aplasia induced by erythropoiesis stimulating agents].
Pure red-cell aplasia is an isolated disorder of erythropoiesis that leads to the pment of severe, isolated anemia. In chronic kidney disease patients treated with n erythropoiesis stimulating agent (ESA), development of anti-erythropoietin antibodies s one of the leading causes of pure red-cell aplasia. It requires to stop treatment with ESA, but in the vast majority of cases immunosuppressive...
متن کاملAcquired pure red cell aplasia.
Correspondence MEDICALTJOSRNAL 559 Acquired Pure Red Cell Aplasia SIR,-May we make the following observation about your article on acquired pure red cell aplasia and its treatment with steroids (6 April, p. 3) ? A pure red cell aplasia that responded to riboflavine or prednisone has been described in African adults and in children with marasmus and kwashiorkor.' In marasmus and kwashiorkor an e...
متن کاملSuccessful reintroduction of a different erythropoiesis-stimulating agent after pure red cell aplasia: relapse after successful therapy with prednisone.
We report a 3-year case history that describes a 78-year-old woman with recurrent transfusion-dependent pure red cell aplasia (PRCA) secondary to recombinant epoetin use that was responsive to immunosuppressant therapy. The patient had kidney disease of unknown aetiology (estimated glomerular filtration rate of 13 ml/min/1.73 m2) and was not on dialysis. After 16 months of therapy with subcutan...
متن کاملMeasurement of anti-erythropoiesis-stimulating agent IgG4 antibody as an indicator of antibody-mediated pure red cell aplasia.
Patients treated with erythropoietin-based erythropoiesis-stimulating agents (ESAs) can develop a rare but life-threatening condition called antibody-mediated pure red cell aplasia (amPRCA). The antibody characteristics in a nephrology patient with amPRCA include high antibody concentrations with neutralizing activity and a mixed IgG subclass including anti-ESA IgG4 antibodies. In contrast, ant...
متن کاملStudies on Pure Red Cell Aplasia
An 1 8-yr-old female with chronic active The patient’s plasma was cytotoxic for hepatitis developed a severe anemia due erythroblasts. Following splenectomy, a to a lack of red cell production. Her bane remission of the disease occurred. This marrow showed many large proerythrostudy indicates that in some cases the blasts but an almost complete lack of more anemia associated with abundant marro...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2008
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfn326